A. Hadfield. Regeneron v Kymab: Transgenic mice claims found insufficient, Vol 12, Issue 13 Pharmaceutical Industry (IPI) journal. (2020)
Mesleh, M. F., Cross, J. B., Zhang, J., Kahmann, J., Andersen, O. A., Barker, J., Cheng, R. K., Felicetti, B., Wood, M., Hadfield, A. T., Scheich, C., Moy, T. I., Yang, Q., Shotwell, J., Nguyen, K., Lippa, B., Dolle, R., and Ryan, M. D. “Fragment-based discovery of DNA gyrase inhibitors targeting the ATPase subunit of GyrB” (2016) Bioorganic & Medicinal Chemistry Letters, 26:1314-1318
Dall’Aglio, P., Arthur, C.J., Williams, C., Vasilakis, K., Maple, H.J., Crosby, J., Crump, M.P. and Hadfield A.T. “Analysis of Streptomyces coelicolor Phosphopantetheinyl Transferase, AcpS, Reveals the Basis for Relaxed Substrate Specificity” (2011) Biochemistry, 50: 5704–5717
Frolov, D., Marsh, M., Crouch, L., Fyfe, P., Robert, B., van Grondelle, R., Hadfield, A.T. and Jones, M.R. “Structural and Spectroscopic Consequences of Hexacoordination of a Bacteriochlorophyll Cofactor in the Rhodobacter sphaeroides Reaction Center” (2010) Biochemistry, 49: 1882-92
Frayne, J., Taylor, A., Cameron, G. and Hadfield, A.T. “Structure of Insoluble Rat Sperm Glyceraldehyde-3-phosphate Dehydrogenase (GAPDH) via Heterotetramer Formation with Escherichia coli GAPDH Reveals Target for Contraceptive Design” (2009) Journal of Biological Chemistry, 284: 22703–22712
Devenish, S.R.A., Huisman, F.R., Parker, E.J., Hadfield, A.T. and Gerrard, J.A. “Cloning and characterisation of dihydrodipicolinate synthase from the pathogen Neisseria meningitides” (2009) Biochimica et Biophysica Acta - Proteins and Proteomics, 1794: 1168–1174
Marsh, M. Shoemark, D.K., Jacob, A., Robinson, C., Cahill, B., Zhou, N.-Y., Williams, P.A. and Hadfield, A.T. “Structure of Bacterial Glutathione-S-Transferase Maleyl Pyruvate Isomerase and Implications for Mechanism of Isomerisation” (2008) Journal of Molecular Biology, 384: 165–177 (including front cover illustration)
Murphy, T.A., Catto, L.E., Halford, S.E., Hadfield, A.T., Minor, W, Walsh, T.R. and Spencer, J. “Crystal structure of Pseudomonas aeruginosa SPM-1 provides insights into variable zinc affinity of metallo-beta-lactamases” (2006) Journal of Molecular Biology, 357: 890-903
Hadfield, A.T. “Electron-induced enzyme activation” (2006) Structure, 14: 1-2
Cox, R.J., Gibson, S. and Hadfield, A.T. "Design, Synthesis and Analysis of inhibitors of Bacterial Aspartate semialdehyde Dehdrogenase" (2005) ChemBioChem, 6: 2255-2260
Hadfield, A.T., Limpkin, C., Teartasin, W., Simpson, T.J., Crosby, J. and Crump, M.P. "The Crystal Structure of the actIII Actinorhodin Polyketide Reductase: Proposed Mechanism for ACP and Polyketide Binding" (2004) Structure, 12: 1865-1875
Teartasin, W., Limpkin, C., Glod, F., Spencer, J., Cox, R.J., Simpson, T.J., Crosby, J., Crump, M. P. and Hadfield A.T. " Expression, purification and preliminary x-ray diffraction analysis of a ketoreductase from a Type II polyketide synthase" (2004) Acta Cryst. D 60: 1137-1138
Hadfield, A.T., Shammas, C., Kryger, G., Ringe, D., Petsko, G.A., Ouyang, J. and Viola R.E. “Active site analysis of the potential anti-microbial target Aspartate semialdehyde dehydrogenase” (2001) Biochemistry, 40: 14475-14483
Cox, R.J.; Hadfield, A.T. and Mayo-Martin M.H. “Difluoromethylene analogues of aspartyl phosphate: the first synthetic inhibitors of aspartate semi-aldehyde dehydrogenase” (2001) Chemical Communications, 1710-1711
Virji, M., Evans, D., Griffith, J., Hill, D., Serino, L., Hadfield, A.T. and Watt, S.M. “Carcinoembryonic antigens are targeted by diverse strains of typeable and non-typeable haemophilus influenzae” (2000) Molecular Microbiology, 36: 784-795
Hadfield, A.T., Diana, G.D. and Rossmann, M.G. “Analysis of three structurally related antiviral compounds in complex with Human Rhinovirus 16.” (1999) Proceedings of the National Academy of Sciences, 96: 14730-14735
Virji, M, Evans, D, Hadfield, A.T., Gunert, F, Teixeira, A.M and Watt, S. “Critical determinants of host receptor targeting by N. meningitidis and N. gonorrhoeae: identification of Opa adhesiotopes on the N-domain of CD66 molecules.” (1999) Molecular Microbiology, 34: 538-551. (including front cover illustration)
Hadfield, A., Kryger G., Petsko G. and Viola, R, “Structure of ASADH from E. coli, a key enzyme in the aspartate family of amino acid biosynthesis” (1999) Journal of Molecular Biology, 289: 991-1002
Hadfield, A.T. and Mulholland, A. J. “Active site dynamics of ASADH - a bacterial biosynthetic enzyme” (1999) International Journal of Quantum Chemistry, Biophys. Quart., 73: 137-146
Hadfield A.T., Petsko, G.A., Lindo P. and Singh, B.-R., “Preliminary crystallographic studies on botulinum neurotoxin type A associated protein Hn-33” (1999) Acta Cryst. D, 55: 1237-1239
Hadfield, A.T., Lee, W.-M., Rueckert, R.R. and Rossmann, M.G. "Refined structure of HRV 16 at 2.15 Å resolution." (1997) Structure, 5: 427-441
Zhao, R., Hadfield, A.T., Kremer, M.J. and Rossmann, M.G. "Cations in human rhinoviruses." (1997) Virology, 227: 13-23
Hadfield, A.T., Oliveira, M.A, Kim, K.H, Minor, I, Kremer, M., Heinz, B.A., Shepard, D., Pevear, D.C., Rueckert, R.R. and Rossmann, M.G. "Structural studies on human rhinovirus 14 drug-resistant compensation mutants." (1995) Journal of Molecular Biology, 253: 61-73
Hadfield, A.T., Chapman, M.S., Hajdu, J. and Rossmann, M.G. “Laue diffraction studies of human rhinovirus and canine parvovirus.” (1995) Acta Cryst. D 51: 859-870
Cornea-Hasegan, M.A., Zhang, Z., Lynch, R.E., Marinescu, D.C., Hadfield, A.T., Muckelbauer, J.K., Munshi, S., Tong, L. and Rossmann, M.G. “Phase refinement and extension by means of non-crystallographic symmetry averaging using parallel computers.” (1995) Acta Cryst. D 51: 749-759
Hadfield, A.T., Harvey, D.J., Archer, D.B., MacKenzie, D.J., Jeenes, D.J., Radford, S.E., Lowe, G., Dobson, C. and Johnson, L.N. “The crystal structure of a mutant D52S hen egg white lysozyme with an oligosaccharide product.” (1994) Journal of Molecular Biology, 243: 856-872
Duke E.M.H., Wakatsuki S., Hadfield A.T. and Johnson L.N. “Laue and monochromatic diffraction studies on catalysis in phosphorylase-B crystals” (1994) Protein Science, 3: 1178-1196
Hadfield, A.T. and Hajdu, J. “On the photochemical release of phosphate from 3,5 dinitrophenyl phosphate in a protein crystal.” (1993) Journal of Molecular Biology, 236: 995-1000
Hadfield, A.T. and Hajdu, J. “A fast and portable micro-spectrophotometer for protein crystallography.” (1993) Journal of Applied Crystallography, 26: 839-842
Duke, E., Hadfield, A.T., Walters, S., Wakatsuki, S., Bryan, R. and Johnson, L. “Time-resolved diffraction studies on glycogen phosphorylase-B” (1992) Phil. Trans. Roy. Soc. A, 340: 245-261
Hadfield, A.T. “Rapid diffraction studies on crystalline biological molecules.” (1992) D. Phil thesis, Laboratory of Molecular Biophysics, Oxford University. Supervisor: Janos Hajdu
Talks and Presentations
2009 British Crystallographic Association Annual Spring Meeting, York
2005 Gordon Conference, ‘Enzymes, Coenzymes and Metabolic Pathways’, New England, USA
2005 Royal Society of Chemistry meeting, ‘Mechanistic Enzymology and Biocatalysis’, Exeter
2004 European Crystallographic Meeting 22, Budapest, Hungary
1998 Invited speaker at “Molecular Structure and Dynamics in Biology” Int. Soc. Quantum Biology and Pharmacology, Italy.
1996 Gordon Research Conf. ‘Diffraction methods’, New England; 28th Crystallography School, Erice