Andrea’s working life has been at the interface between Biotechnology, Physics and Chemistry. She holds an honours degree in Physics and a DPhil in Structural Biology from Oxford University.
 
As a Patent Attorney, Andrea’s technical expertise spans the life sciences and extends to cross-technology areas, including amplification and sequencing technologies (next generation sequencing), antibodies and immunology, bioinformatics and genomics, epigenetics, modified and thermostable enzymes, vaccines, fermentation, and bone/cartilage regeneration.
 
Andrea has experience working for a wide range of clients, including universities, spinouts, SMEs and multinational corporate clients. She drafts and prosecutes applications for and in the UK, Europe and worldwide. Her clients have sought her counsel for European Patent Office opposition and appeal work, the management of European patent portfolios and advice on infringement and validity issues.
 
Before qualifying as a Patent Attorney, Andrea carried out independent research focussed on enzymes and viruses at a molecular level, including the binding of reaction intermediates and drug leads using techniques including time resolved crystallography. After Postdocs in the United States, she led a research group and lectured in Biochemistry at the University of Bristol followed by research at a “major player” drug discovery company.

Andrea is also an Oxford blue, and was President of the Oxford University Women’s Boat Club (1990-1991) and enjoys sugarcraft and cake-decorating – and made three tier wedding cakes for all her siblings and siblings-in-law.

Qualifications

Cert. IP. Queen Mary 2015
EPA July 2018
CPA April 2019
 

Memberships

Biochemical Society
British Crystallographic Association

A. Hadfield. Regeneron v Kymab: Transgenic mice claims found insufficient, Vol 12, Issue 13 Pharmaceutical Industry (IPI) journal. (2020) 

Mesleh, M. F., Cross, J. B., Zhang, J., Kahmann, J., Andersen, O. A., Barker, J., Cheng, R. K., Felicetti, B., Wood, M., Hadfield, A. T., Scheich, C., Moy, T. I., Yang, Q., Shotwell, J., Nguyen, K., Lippa, B., Dolle, R., and Ryan, M. D. “Fragment-based discovery of DNA gyrase inhibitors targeting the ATPase subunit of GyrB” (2016) Bioorganic & Medicinal Chemistry Letters, 26:1314-1318

Dall’Aglio, P., Arthur, C.J., Williams, C., Vasilakis, K., Maple, H.J., Crosby, J., Crump, M.P. and Hadfield A.T. “Analysis of Streptomyces coelicolor Phosphopantetheinyl Transferase, AcpS, Reveals the Basis for Relaxed Substrate Specificity” (2011) Biochemistry, 50: 5704–5717

Frolov, D., Marsh, M., Crouch, L., Fyfe, P., Robert, B., van Grondelle, R., Hadfield, A.T. and Jones, M.R. “Structural and Spectroscopic Consequences of Hexacoordination of a Bacteriochlorophyll Cofactor in the Rhodobacter sphaeroides Reaction Center” (2010) Biochemistry, 49: 1882-92

Frayne, J., Taylor, A., Cameron, G. and Hadfield, A.T. “Structure of Insoluble Rat Sperm Glyceraldehyde-3-phosphate Dehydrogenase (GAPDH) via Heterotetramer Formation with Escherichia coli GAPDH Reveals Target for Contraceptive Design” (2009) Journal of Biological Chemistry, 284: 22703–22712

Devenish, S.R.A., Huisman, F.R., Parker, E.J., Hadfield, A.T. and Gerrard, J.A. “Cloning and characterisation of dihydrodipicolinate synthase from the pathogen Neisseria meningitides” (2009) Biochimica et Biophysica Acta - Proteins and Proteomics, 1794: 1168–1174

Marsh, M. Shoemark, D.K., Jacob, A., Robinson, C., Cahill, B., Zhou, N.-Y., Williams, P.A. and Hadfield, A.T. “Structure of Bacterial Glutathione-S-Transferase Maleyl Pyruvate Isomerase and Implications for Mechanism of Isomerisation” (2008) Journal of Molecular Biology, 384: 165–177 (including front cover illustration)

Murphy, T.A., Catto, L.E., Halford, S.E., Hadfield, A.T., Minor, W, Walsh, T.R. and Spencer, J.  “Crystal structure of Pseudomonas aeruginosa SPM-1 provides insights into variable zinc affinity of metallo-beta-lactamases” (2006) Journal of Molecular Biology, 357: 890-903

Hadfield, A.T.  “Electron-induced enzyme activation” (2006) Structure, 14: 1-2

Cox, R.J., Gibson, S. and Hadfield, A.T.  "Design, Synthesis and Analysis of inhibitors of Bacterial Aspartate semialdehyde Dehdrogenase" (2005) ChemBioChem, 6: 2255-2260

Hadfield, A.T., Limpkin, C., Teartasin, W., Simpson, T.J., Crosby, J. and Crump, M.P. "The Crystal Structure of the actIII Actinorhodin Polyketide Reductase: Proposed Mechanism for ACP and Polyketide Binding" (2004) Structure, 12: 1865-1875

Teartasin, W., Limpkin, C., Glod, F., Spencer, J., Cox, R.J., Simpson, T.J., Crosby, J., Crump, M. P. and Hadfield A.T.  " Expression, purification and preliminary x-ray diffraction analysis of a ketoreductase from a Type II polyketide synthase" (2004) Acta Cryst. D 60: 1137-1138

Hadfield, A.T., Shammas, C., Kryger, G., Ringe, D., Petsko, G.A., Ouyang, J. and Viola R.E. “Active site analysis of the potential anti-microbial target Aspartate semialdehyde dehydrogenase” (2001) Biochemistry, 40: 14475-14483

Cox, R.J.; Hadfield, A.T. and Mayo-Martin M.H. “Difluoromethylene analogues of aspartyl phosphate: the first synthetic inhibitors of aspartate semi-aldehyde dehydrogenase” (2001) Chemical Communications, 1710-1711

Virji, M., Evans, D., Griffith, J., Hill, D., Serino, L., Hadfield, A.T. and Watt, S.M. “Carcinoembryonic antigens are targeted by diverse strains of typeable and non-typeable haemophilus influenzae” (2000) Molecular Microbiology, 36: 784-795

Hadfield, A.T., Diana, G.D. and Rossmann, M.G. “Analysis of three structurally related antiviral compounds in complex with Human Rhinovirus 16.” (1999) Proceedings of the National Academy of Sciences, 96: 14730-14735

Virji, M, Evans, D, Hadfield, A.T., Gunert, F, Teixeira, A.M and Watt, S. “Critical determinants of host receptor targeting by N.  meningitidis and N.  gonorrhoeae: identification of Opa adhesiotopes on the N-domain of CD66 molecules.” (1999) Molecular Microbiology, 34: 538-551. (including front cover illustration)

Hadfield, A., Kryger G., Petsko G. and Viola, R, “Structure of ASADH from E. coli, a key enzyme in the aspartate family of amino acid biosynthesis” (1999) Journal of Molecular Biology, 289: 991-1002

Hadfield, A.T. and Mulholland, A. J. “Active site dynamics of ASADH - a bacterial biosynthetic enzyme” (1999) International Journal of Quantum Chemistry, Biophys. Quart., 73: 137-146

Hadfield A.T., Petsko, G.A., Lindo P. and Singh, B.-R., “Preliminary crystallographic studies on botulinum neurotoxin type A associated protein Hn-33” (1999) Acta Cryst. D, 55: 1237-1239

Hadfield, A.T., Lee, W.-M., Rueckert, R.R. and Rossmann, M.G. "Refined structure of HRV 16 at 2.15 Å resolution."  (1997) Structure, 5: 427-441

Zhao, R., Hadfield, A.T., Kremer, M.J. and Rossmann, M.G. "Cations in human rhinoviruses."  (1997) Virology, 227: 13-23

Hadfield, A.T., Oliveira, M.A, Kim, K.H, Minor, I, Kremer, M., Heinz, B.A., Shepard, D., Pevear, D.C., Rueckert, R.R. and Rossmann, M.G. "Structural studies on human rhinovirus 14 drug-resistant compensation mutants."  (1995) Journal of Molecular Biology, 253: 61-73

Hadfield, A.T., Chapman, M.S., Hajdu, J. and Rossmann, M.G. “Laue diffraction studies of human rhinovirus and canine parvovirus.”  (1995) Acta Cryst. D 51: 859-870

Cornea-Hasegan, M.A., Zhang, Z., Lynch, R.E., Marinescu, D.C., Hadfield, A.T., Muckelbauer, J.K., Munshi, S., Tong, L. and Rossmann, M.G. “Phase refinement and extension by means of non-crystallographic symmetry averaging using parallel computers.” (1995) Acta Cryst. D 51: 749-759

Hadfield, A.T., Harvey, D.J., Archer, D.B., MacKenzie, D.J., Jeenes, D.J., Radford, S.E., Lowe, G., Dobson, C. and Johnson, L.N. “The crystal structure of a mutant D52S hen egg white lysozyme with an oligosaccharide product.” (1994) Journal of Molecular Biology, 243: 856-872

Duke E.M.H., Wakatsuki S., Hadfield A.T. and Johnson L.N. “Laue and monochromatic diffraction studies on catalysis in phosphorylase-B crystals” (1994) Protein Science, 3: 1178-1196

Hadfield, A.T. and Hajdu, J. “On the photochemical release of phosphate from 3,5 dinitrophenyl phosphate in a protein crystal.”  (1993) Journal of Molecular Biology, 236: 995-1000

Hadfield, A.T. and Hajdu, J. “A fast and portable micro-spectrophotometer for protein crystallography.”  (1993) Journal of Applied Crystallography, 26: 839-842

Duke, E., Hadfield, A.T., Walters, S., Wakatsuki, S., Bryan, R. and Johnson, L. “Time-resolved diffraction studies on glycogen phosphorylase-B” (1992) Phil. Trans. Roy. Soc. A, 340: 245-261

Hadfield, A.T. “Rapid diffraction studies on crystalline biological molecules.” (1992) D. Phil thesis, Laboratory of Molecular Biophysics, Oxford University. Supervisor: Janos Hajdu

 

Talks and Presentations

2009     British Crystallographic Association Annual Spring Meeting, York
2005     Gordon Conference, ‘Enzymes, Coenzymes and Metabolic Pathways’, New England, USA
2005     Royal Society of Chemistry meeting, ‘Mechanistic Enzymology and Biocatalysis’, Exeter
2004     European Crystallographic Meeting 22, Budapest, Hungary
1998     Invited speaker at “Molecular Structure and Dynamics in Biology” Int. Soc. Quantum Biology and Pharmacology, Italy.
1996     Gordon Research Conf. ‘Diffraction methods’, New England; 28th Crystallography School, Erice

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