“Neurim-style SPCs” CIPA Journal 2016, 45(8-9): 16-18.
“SPC term: set in stone?” CIPA Journal 2017, 46(7-8): 32-33.
“What constitutes a ‘new’ active ingredient under Article 1(b)?” CIPA Journal 2018, 47(7-8): 12-13.
Selected scientific publications:
“Expanding the genetic code of yeast for incorporation of diverse unnatural amino acids via a pyrrolysyl-tRNA synthetase/tRNA pair.”
Hancock SM, Uprety R, Deiters A, Chin JW. J. Am. Chem. Soc. 2010, 132(42): 14819
“A method for genetically installing site-specific acetylation in recombinant histones defines the effects of H3 K56 acetylation.”
Neumann H, Hancock SM, Buning R, Routh A, Chapman L, Somers J, Owen-Hughes T, van Noort J, Rhodes D, Chin JW. Mol. Cell. 2009, 36(1):153-63.
“Designer enzymes for glycosphingolipid synthesis by directed evolution.”
Hancock SM, Rich JR, Caines ME, Strynadka NC, Withers SG. Nat. Chem. Biol. 2009, 5(7): 508
“The structural basis of glycosidase inhibition by five-membered iminocyclitols: the clan a glycoside hydrolase endoglycoceramidase as a model system.”
Caines ME, Hancock SM, Tarling CA, Wrodnigg TM, Stick RV, Stütz AE, Vasella A, Withers SG, Strynadka NC. Angew. Chem. Int. Ed. Engl. 2007, 46(24): 4474
“High-throughput screening of cell lysates for ganglioside synthesis.”
Hancock SM, Tarling CA, Withers SG. Anal. Biochem. 2008, 382(1): 48
“Engineering of glycosidases and glycosyltransferases.”
Hancock SM, Vaughan MD, Withers SG. Curr. Opin. Chem. Biol. 2006, 10(5): 509
“Structural and mechanistic analyses of endo-glycoceramidase II, a membrane-associated family 5 glycosidase in the Apo and GM3 ganglioside-bound forms.”
Caines ME, Vaughan MD, Tarling CA, Hancock SM, Warren RA, Withers SG, Strynadka NC. J. Biol Chem. 2007, 282(19): 14300
“A front-face 'SNi synthase' engineered from a retaining 'double-SN2' hydrolase.”
Iglesias-Fernández J, Hancock SM, Lee SS, Khan M, Kirkpatrick J, Oldham NJ, McAuley K, Fordham-Skelton A, Rovira C, Davis BG. Nat. Chem. Biol. 2017, 13(8): 874
“Developing promiscuous glycosidases for glycoside synthesis: residues W433 and E432 in Sulfolobus solfataricus beta-glycosidase are important glucoside- and galactoside-specificity determinants.”
Hancock SM, Corbett K, Fordham-Skelton AP, Gatehouse JA, Davis BG. Chembiochem. 2005, 6(5): 866